
- MIT Sponsors:- Robert T. Sauer, Department of Biology
 
- Scholar Link:Visit Jason K. Sello's faculty page
Through our scientific and technological genius, we've made of this world a neighborhood. And now through our moral and ethical commitment, we must make of it a brotherhood.
Background
Jason K. Sello is an associate professor in the Department of Chemistry at Brown University. He earned a PhD in biophysics from Harvard University in 2002 and a BS in biology from Morehouse College in 1997.
Interests
In his independent career, Sello has been synergistically using experimental methods from chemistry, molecular biology, biochemistry, and genomics to develop new anti-infectives and biotechnology platforms for the conversion of plant biomass to biofuels and commodity chemicals. At MIT, he worked collaboratively with Prof. Robert T. Sauer in the Department of Biology on antibacterial agents that act by critically perturbing protein turnover in bacteria.
Sample Work
- Publication- Study of PcaV from Streptomyces coelicolor Yields New Insights into Ligand-Responsive MarR Family Transcription Factors- Davis, J. R., Brown, B. L., Page, R., Sello, J. K. (2013) “Study of PcaV from Streptomyces coelicolor Yields New Insights into Ligand-Responsive MarR Family Transcription Factors”. Nucleic Acids Research. 41: 3888-900. PMID: 23396446 
- Publication- Genome Sequence of Streptomyces viridosporus T7A ATCC 39115, a Lignin-Degrading Actinomycete- Davis, J. R., Goodwin, L., Teshima, H., Detter, C., Tapia, R., Han, C., Huntemann, M., Wei, C.-L., Han, J., Chen, A, Kyrpides, N., Mavrommatis, K., Szeto, E., Markowitz, V., Ivanova, N, Mikhailova, N., Ovchinnikova, G., Pagani, I., Pati, A., Woyke, T., Pitluck, S., Peters, L., Nolan, M., Land, M., Sello, J.K. (2013) “Genome Sequence of Streptomyces viridosporus T7A ATCC 39115, a Lignin-Degrading Actinomycete”. Genome Announcements, 1(4): e00416-13. PMID: 23833133. 
- Publication- Antibacterial of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase- Compton, C. L., Schmitz, K. R., Sauer, R. T. Sello, J. K. (2013) “Antibacterial of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase”. ACS Chemical Biology, Epub Ahead of Print. PMID: 24047344 
- Publication- A retrograde trafficking inhibitor of ricin and shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses- Nelson, C., Carney, D. W., Derdowski, A, Lipovsky, A, Gee, G., O’Hara, B., Williard, P., DiMaio, D., Sello, J. K., Atwood, W. (2013) “A retrograde trafficking inhibitor of ricin and shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses”. mBio, accepted. 
