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Background
Omolola (Lola) Eniola-Adefeso is a professor of chemical engineering, professor of biomedical engineering, and professor of macromolecular science and engineering at the University of Michigan. Eniola-Adefeso holds an MSE and a PhD, both in chemical and biomolecular engineering, from the University of Pennsylvania. She earned a BSE in chemical and biomolecular engineering from the University of Michigan.
Interests
Eniola-Adefeso’s research aims to use knowledge of the cellular inflammatory response and blood flow dynamics to design bio-functionalized particles for targeted drug delivery and imaging. Due to their high specific interaction with their counter-receptors and their carefully regulated expression (limit to inflammation), leukocyte-endothelium adhesion molecules (LECAM) are attractive molecules for vascular targeting in human diseases in which inflammation plays a role. Eniola-Adefso’s contributions also include a 2021 article in Cell, calling out the racial funding disparity by the National Institutes of Health and the impact that disparity has on academic research and teaching.
Sample Work
Publication
Effect of PEGylation on Ligand-Based Targeting of Drug Carriers to the Vascular Wall in Blood Flow
Onyskiw, P. and O. Eniola-Adefeso. (2013) “Effect of PEGylation on Ligand-Based Targeting of Drug Carriers to the Vascular Wall in Blood Flow.” Langmuir. 2013. 29(35):11127-34.
Publication
The Margination Propensity of Ellipsoidal Micro/Nanoparticles to the Endothelium in Human Blood Flow
Thompson, A.J., E.M. Mastria, O. Eniola-Adefeso (2013) “The Margination Propensity of Ellipsoidal Micro/Nanoparticles to the Endothelium in Human Blood Flow.” Biomaterials. 2013. 34(23):5863-71.
Publication
Laminar Shear Stress Elicit Distinct Endothelial Cell E-Selectin Expression Pattern via TNFα and IL-1β Activation
Huang, R.B., A.L. Gonzalez, and O. Eniola-Adefeso. (2013) “Laminar Shear Stress Elicit Distinct Endothelial Cell E-Selectin Expression Pattern via TNFα and IL-1β Activation.” Biotechnology & Bioengineering. 2013. 110(3): 999-1003.
Publication
Margination propensity of vascular-targeted spheres from blood flow in a microfluidic model of human microvessels
Namdee, K., A.J. Thompson, P. Charoenphol and O. Eniola-Adefeso. (2013) “Margination propensity of vascular-targeted spheres from blood flow in a microfluidic model of human microvessels.” Langmuir. 2013. 29(8): 2530-2535