Jason Sello and MIT colleagues publish paper on “a cellular garbage disposal”

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Jason Sello and his colleagues at Brown and MIT will be published in the Proceedings of the National Academy of Sciences this month. The paper is entitled “Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery”. Sello’s co-authors are MIT’s Prof. Robert Sauer (Sello’s MLK faculty host) and Karl R. Schmitza, as well as Brown University’s Daniel W. Carneyb.

The research shows “new details about how a promising new class of antibiotics attacks the bacterium that causes tuberculosis” and “could provide a blueprint for developing drugs aimed at fighting TB.”